The Opportunity Map · Particella

Particella's platform addresses 55 indications across seven therapeutic categories using gut-targeted mechanism.

Indication selection below is based on mechanism where Particella can be best-in-class or first-in-class.

1 10 100 1k 10k 100k 1M 10M+ IBD & gut-immune Functional GI Hereditary CRC + chemoprev IEMs (inborn errors of metabolism) Cardio- metabolic Gut-organ axis Growth / wasting US prevalence (log scale) SEVERITY High mortality >2× / pediatric-lethal Medium mortality 1.2–2× / lifetime burden Low QoL-dominant on SoC Celiac disease Eosinophilic GI disease (EoE primary) Phenylketonuria (PKU) Hereditary hemochromatosis ALDH2 deficiency / acetaldehyde CRC prev (scope-narrowed from UADT cancers per red-team) Hereditary fructose intolerance Microscopic colitis CF GI manifestations Bile-acid diarrhea (BAM) Chronic constipation / IBS-C Sucrase-isomaltase deficiency (CSID) Hyperuricemia / gout Serrated polyposis syndrome (SPS) Irritable bowel syndrome (all subtypes) Functional dyspepsia Pregnancy/lactation GI disorders Pediatric growth disorders + FTT Congenital chloride diarrhea Lactose intolerance (adult-type) Iron deficiency anemia (refractory) Secondary / enteric hyperoxaluria Inflammatory bowel disease (adult sporadic) Obesity Lynch syndrome (chemoprev) Recurrent C. difficile infection Gastroparesis Familial adenomatous polyposis (FAP) MUTYH-associated polyposis (MAP) Intestinal cholesterol absorption / refractory hyperlipidemia Chemo/radiation-induced mucositis Juvenile polyposis syndrome (JPS) Hirschsprung-associated enterocolitis (HAEC) Pancreatic enzyme insufficiency (PEI) Tyrosinemia Type 1 Adult-onset IBD-associated monogenic enteropathies Maple syrup urine disease (MSUD) Homocystinuria (classic, CBS deficiency) Sitosterolemia Small intestinal bacterial overgrowth (SIBO) Hepatic encephalopathy GVHD of the gut Short bowel syndrome Hyperphosphatemia in CKD Sarcopenia / frailty Peutz-Jeghers syndrome Cancer cachexia Alcoholic liver disease Very-early-onset IBD (VEO-IBD) IgA nephropathy Cholestatic pruritus (Alagille + PFIC) Necrotizing enterocolitis (NEC) Intestinal failure-associated liver disease MMA / PA (methylmalonic + propionic acidemia) Urea cycle disorders (UCDs) Crigler-Najjar (CN-1 + refractory CN-2)